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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, doi: 10.15302/J-FASE- 2021390

Abstract: This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophanwith triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylaminepreparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouseand field experiments, and toxicity tests.NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field

Keywords： antiviral plant protectant / antiviral in the greenhouse / field evaluation / l-trp-NCA / synthesis optimization/ toxicity tests    

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG

Frontiers of Agricultural Science and Engineering   Pages 110-119 doi: 10.15302/J-FASE-2021390

Abstract: This study optimized a route for two-step synthesis of this virucide candidate via reaction of L-tryptophanwith triphosgene to produce L-tryptophan- -carboxylic anhydride, which then reacts with -octylaminepreparation of NK0238 on a > 40 g scale permitting further assessment of its antivirus activity in the greenhouseand field experiments, and toxicity tests.NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field

Keywords： antiviral plant protectant     antiviral in the greenhouse     field evaluation     L-trp-NCA     synthesis optimization     toxicity tests    

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Field scale measurement of greenhouse gas emissions from land applied swine manure

Devin L. Maurer, Jacek A. Koziel, Kelsey Bruning

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 3, doi: 10.1007/s11783-017-0915-9

Abstract: Greenhouse gas emissions (GHGs) from swine production systems are relatively well researched with theobservational study was to measure GHG fluxes from land application of swine manure on a typical corn field

Keywords： Climate change     Emissions     Greenhouse gases     Land application     Swine manure    

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Enhanced Fenton-like process over Cu/L(+)-ascorbic acid co-doping mesoporous silica for toxicity reduction

Frontiers of Environmental Science & Engineering 2023, Volume 18, Issue 4, doi: 10.1007/s11783-024-1804-7

Abstract:

● Cu-C-MSNs are developed via a co-doping step of Cu with L(+)-ascorbic

Keywords： Cation-π structures     Polarization electric field     Fenton-like process     Contaminants cleavage    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: Their potent antiviral properties indicated the prospect of new drugs.

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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Size-controlled green synthesis of silver nanoparticles assisted by L-cysteine

Wenchao Zhang,Lin Zhang,Yan Sun

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 4,   Pages 494-500 doi: 10.1007/s11705-015-1527-1

Abstract: A green and size-controlled synthesis of silver nanoparticles (Ag NPs) in aqueous solution with the assistanceof L-cysteine is presented.The size of Ag NPs decreases with the increase of L-cysteine concentration, and thus can be controlledby adjusting L-cysteine concentration.L-cysteine, about one sixth of the size of Ag NPs obtained in the absence of L-cysteine (17 nm).

Keywords： nanoparticles     silver     L-cysteine     size distribution     synthesis    

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Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse

Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1,   Pages 89-98 doi: 10.1007/s11783-013-0591-3

Abstract: The relationship between the chemical contaminants and soil microbial toxicity of waste foundry sandThe soil microbial toxicity of each WFS was evaluated by measuring the dehydrogenase activity (DHA) of, the WFSs with higher concentrations of metal and organic contaminants exhibited greater microbial toxicity

Keywords： waste foundry sand     toxicity     bioassay     soil microbial activity     waste reuse    

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Identification of important precursors and theoretical toxicity evaluation of byproducts driving cytotoxicity

Qian-Yuan Wu, Yi-Jun Yan, Yao Lu, Ye Du, Zi-Fan Liang, Hong-Ying Hu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 2, doi: 10.1007/s11783-019-1204-6

Abstract: amino acids formed more N-DBPs during chlorination • Aspartic acid and asparagine showed the highest toxicityusing a theoretical toxicity evaluation of contributions to the cytotoxicity index (CTI) and genotoxicityAmong the DBPs, DCAN had the largest contribution to the toxicity index and might be the main driverof toxicity.Among the precursors, aspartic acid and asparagine gave the highest DCAN concentration (200 g/L) and

Keywords： Chlorination     Dichloroacetonitrile     Aspartic acid     Asparagine     Toxicity index    

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A regularization scheme for explicit level-set XFEM topology optimization

GEISS, Jorge L. BARRERA, Narasimha BODDETI, Kurt MAUTE

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 2,   Pages 153-170 doi: 10.1007/s11465-019-0533-2

Abstract: Regularization of the level-set (LS) field is a critical part of LS-based topology optimization (TO)Traditionally this is achieved by advancing the LS field through the solution of a Hamilton-Jacobi equationThis paper introduces a novel LS regularization approach based on a signed distance field (SDF) whichThe SDF is obtained using the heat method (HM) and is reconstructed for every design in the optimizationdimensions are presented to show the applicability of the proposed scheme to a broad range of design optimization

Keywords： level-set regularization     explicit level-sets     XFEM     CutFEM     topology optimization     heat method     signed distancefield     nonlinear structural mechanics     fluid mechanics    

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A MATLAB code for the material-field series-expansion topology optimization method

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 3,   Pages 607-622 doi: 10.1007/s11465-021-0637-3

Abstract: This paper presents a MATLAB implementation of the material-field series-expansion (MFSE) topo-logy optimizationThe MFSE method uses a bounded material field with specified spatial correlation to represent the structuralWith the series-expansion method for bounded fields, this material field is described with the characteristicThe implementation of the code and its extensions to topology optimization problems with multiple loadMFSE topology optimization method with non-gradient optimization algorithms without sensitivity information

Keywords： MATLAB implementation     topology optimization     material-field series-expansion method     bounded materialfield     dimensionality reduction    

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Synthesis and characterization of well-defined comb-like branched polymers

LI Aixiang, LU Zaijun, LÜ Zijian

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 4,   Pages 407-411 doi: 10.1007/s11705-008-0064-6

Abstract: Well-defined comb-like branched polymers having one branch in each repeating unit have been successfully synthesized by the coupling reaction of living polystyrene (PS) and polyisoprene (PI) anions with 1, 1-diphenylethenyl (DPE) groups along PS backbone prepared via atom transfer radical polymerization (ATRP) of 4-vinylbenzyloxy benzophenone (Sc) followed by Wittig reaction. The resulting comb-like branched polymers were characterized by IR, H-NMR, gel permeation chromatography (GPC) and static light scattering (SLS) in detail. The effect of living chains and DPE group molar ratio on grafting efficiency was discussed. The results show the coupling reaction of living chains and DPE groups was highly effective, and the coupling efficiency can be controlled via the feed molar ratios of living chains and DPE groups. Moreover, the effect of molecular weights of backbone (PSe) and PSLi or PILi on grafting efficiency was also discussed. The results show that when excess living polymers were used, the almost quantitative grafting efficiency could be achieved.

Keywords： grafting efficiency     polyisoprene     quantitative grafting     effective     molecular    

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Synergistic optimization framework for the process synthesis and design of biorefineries

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 251-273 doi: 10.1007/s11705-021-2071-9

Abstract: We propose a novel framework incorporating superstructure optimization and simulation-based optimizationIn this context, several approaches for superstructure optimization based on different surrogate modelsThe results indicate that even though surrogate-based optimization approaches alleviate the underlyingFurthermore, the framework’s synergistic effects by sequentially performing superstructure optimizationThese findings invite for a critical assessment of surrogate-based optimization approaches and point

Keywords： biotechnology     surrogate modelling     superstructure optimization     simulation-based optimization     process    

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Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 2,   Pages 220-223 doi: 10.1007/s11705-008-0041-0

Abstract: L-4-Fluorophenylalanine (FPhe) was prepared from 4-fluorophenylpyruvate (FPPA) catalyzed by aspartateconditions: 37°C, pH value range of 5.0–8.0, 5.5 mass ratio of cell to FPPA, 0.6% (w/v) of Tween 80, 7.08 g/LFPPA, and 1.6 of molar ratio of L-Asp to FPPA.

Keywords： L-4-Fluorophenylalanine     Asp-AT     aspartate aminotransferase     4-fluorophenylpyruvate     FPPA    

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Synthesis of depsipeptides from

Hongfei CAO, Yakai FENG, Heyun WANG, Li ZHANG, Musammir KHAN, Jintang GUO

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 4,   Pages 409-415 doi: 10.1007/s11705-011-1141-9

Abstract: By using the corresponding -amino acid sodium as initiator, -caprolactone-depsipeptides CL-Ala and CL-Leu were prepared by the reactions of -caprolactone (CL) with -alanine and -leucine, respectively, and -dioxanone-depsipeptide (PDO-Leu) was prepared by the reaction of -dioxanone (PDO) with -leucine. Two poly( -caprolactone) oligomers (PCL-Ala and PCL-Leu) of different molecular weights with depsipeptide unit were synthesized by controlling the feed ratio of -amino acid sodium and CL. The presence of the depsipeptide structure in these obtained products was confirmed by H NMR spectra and the molecular weight of the poly( -caprolactone) oligomers was measured by gel permeation chromatography (GPC). These products contain a hydroxyl group and a carboxyl group in one molecule, which means they could act as bifunctional monomers for further polymerization to prepare high molecular weight polymers. By this way, the depsipeptide unit could be introduced into the polymers and the biodegradation rates of the novel polymers could be well controlled in vivo by the tailored molecular structures.

Keywords： -caprolactone     p-dioxanone     L-alanine     L-leucine    

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Real atom economy and its application for evaluation the green degree of a process

Weihan WANG, Jing Lü, Li ZHANG, Zhenhua LI

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 349-354 doi: 10.1007/s11705-010-1030-7

Abstract: Green chemistry has attracted more attention in the past century. Among the 12 principles of green chemistry, only atom economy and E factor can be expressed quantitatively to depict the impact of a chemical process to environment. Atom economy was thought better than the traditional yield for evaluating the atom efficiency of raw materials. But it is not enough to reflect the conversion degree of raw material. In this paper, we proposed the concept of real atom economy (RAE) as a metric. RAE could combine the above two factors together to better express the green degree of a process. We further suggested an equation to correlate E factor with RAE. The concept of RAE is proved to be helpful for estimating an environmentally benign process.

Keywords： green chemistry     real atom economy     E factor     atom economy     yield    

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Title Author Date Type Operation

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Journal Article

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG

Journal Article

Field scale measurement of greenhouse gas emissions from land applied swine manure

Devin L. Maurer, Jacek A. Koziel, Kelsey Bruning

Journal Article

Enhanced Fenton-like process over Cu/L(+)-ascorbic acid co-doping mesoporous silica for toxicity reduction

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

Size-controlled green synthesis of silver nanoparticles assisted by L-cysteine

Wenchao Zhang,Lin Zhang,Yan Sun

Journal Article

Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse

Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG

Journal Article

Identification of important precursors and theoretical toxicity evaluation of byproducts driving cytotoxicity

Qian-Yuan Wu, Yi-Jun Yan, Yao Lu, Ye Du, Zi-Fan Liang, Hong-Ying Hu

Journal Article

A regularization scheme for explicit level-set XFEM topology optimization

GEISS, Jorge L. BARRERA, Narasimha BODDETI, Kurt MAUTE

Journal Article

A MATLAB code for the material-field series-expansion topology optimization method

Journal Article

Synthesis and characterization of well-defined comb-like branched polymers

LI Aixiang, LU Zaijun, LÜ Zijian

Journal Article

Synergistic optimization framework for the process synthesis and design of biorefineries

Journal Article

Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping

Journal Article

Synthesis of depsipeptides from

Hongfei CAO, Yakai FENG, Heyun WANG, Li ZHANG, Musammir KHAN, Jintang GUO

Journal Article

Real atom economy and its application for evaluation the green degree of a process

Weihan WANG, Jing Lü, Li ZHANG, Zhenhua LI

Journal Article